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MicroRNA Plasma Markers for Small-for-Gestational-Age (SGA) Births
Markers to determine the risk of SGA births based on miRNA plasma detected from maternal blood samples
Background
Small-for-gestational-age (SGA) babies are neonates whose birth-weight is less than the 10th percentile for the gestational age. Preterm SGA birth has been shown to double the risk of subsequent stillbirth. There are currently around 665,000 babies born in England each year, but despite falling to its lowest rate in 20 years, there are around 3,000 stillbirths, with one in every 200 babies stillborn. According to the WHO, 23 high-income countries have lower stillbirth rates than the UK. One of the key factors that reduced the rate of stillborn according to the NHS is better detection of small babies attributed to better monitoring and scanning in pregnancy. Despite this, current screening practices of high-risk patients still fail to detect approximately
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