Next Generation Boron Neutron Capture Therapy (BNCT)
A new boron drug OKD-001 and a new neutron generator to improve boron neutron capture therapy
Background
Boron Neutron Capture Therapy (BNCT) is positioned as one of the particle therapy methods. After a large amount of boron isotope 10B is delivered to individual cancer cells, low-energy thermal neutrons are irradiated to induce a nuclear reaction, and only cancer cells are killed by the high-energy alpha rays and Li nuclei produced. The resulting high-energy alpha rays and Li nuclei kill only the cancer cells.
Technology Overview
The NextGen BNCT Project aims to achieve a high quality of life for patients with refractory cancers such as hematologic cancers and malignant brain tumors (glioblastoma: GBM) by applying the new boron drug OKD-001 and a new neutron generator ().
Publications
- Design of Beam Shaping Assembly for an Accelerator-driven BNCT System in Nagoya University
- Improved Design of the Exit of a Beam Shaping Assembly for an Accelerator-driven BNCT System in Nagoya University
Benefits
A neutron irradiation service for autologous hematopoietic stem cell transplantation using extracorporeal boron neutron capture therapy, which allows for an early project start under the Medical Practitioners Act.
Applications
Leading patients with hematologic cancers (multiple myeloma MM, leukemia, malignant lymphoma ML) to a complete response.