Background

The main problem with chemotherapy is non-selectivity. This non-selectivity leads to the death of both cancer and normal cells, leading to severe adverse side effects such as bone marrow depression, neuropathy, nephropathy, GIT disorders and Hair loss. Doxorubicin (DOX), a common hemotherapeutic agent used for the treatment of various cancers such as breast, lung and ovarian cancer. DOX is an anthracyline drug that possesses potent anticancer activity. The clinical use of DOX remains limited due to its fatal side effects, the most noted being its dose-dependent Cardiotoxicity. Besides its cardiotoxicity, DOX also suffers from having a short half-life, a rapid elimination from the bloodstream, and as a result low bioavailability at tumor site. This low bioavailability allows only partial