Background

Chronic itch is a common symptom in atopic dermatitis (AD) affecting millions of people and animals, but its mechanisms are not fully understood or explained. AD has high impact on the health of patients due to elevated risks of comorbities such as arthritis, asthma, or allergic rhinitis. AD is also associated with a high prevalence of anxiety, depression and sleep disorders which can significantly affect the quality of life and work productivity. While recent findings have improved understanding of the itch sensation in mice and humans, additional research is needed to fully understand and successfully treat chronic itch and other related diseases such as, psoriasis, eczema, multiple sclerosis, allergic reactions, shingles, diabetes, itch associated with cancer (e.g. lymphoma), and