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hiPSC-derived Oligodendrocyte Progenitors

Oligodendrocytes are one of the glial cell populations present in the central nervous system that support neuronal function. Oligodendrocytes are responsible for generation of myelin sheath, a fatty substance that insulates the nerves and facilitates transmission of electrical signal between neurons. These cells are involved in leukodystrophies, a group of genetic disorders that are caused by progressive destruction of myelin sheath that leads to impaired brain function like loss of hearing and vision, movement disorders and developmental delays. One of the main hurdles in using oligodendrocytes in vitro for drug discovery and disease modeling of myelin loss-related diseases, is long differentiation protocols with low yields that make it challenging to translate them to large-scale production.

Using HD-DoE method, Trailhead Biosystems

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