Background

• Problem: Amyotrophic lateral sclerosis (ALS) is a severe degenerative disease with current treatment being two FDA approved drugs with limited efficacy.
• Solution: Adipose-derived stem cell conditioned media (ASC-CM) is a promising, close-to-IND-ready therapy for ALS.
• Unique value proposition: The ASC-CM formulation has a consistent profile of factors that can influence both the central nervous system and the peripheral nerves.

Technology Overview

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with a global incidence of about 1 per 50,000 people. There are only two FDA approved drugs for the treatment of ALS with only marginal therapeutic benefits in a subset of patients. These, along with other therapies in development, target primarily the central nervous system, allowing