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Novel Vanadium Complexes to Treat Solid Tumors
Novel treatment for highly aggressive brain cancer with increased stability and permeability in cell membranes

Background
Novel therapeutics are required for difficult-to-treat cancers, including brain, lung and pancreatic cancers, in which stabilized formulations of strongly cytotoxic or immune-modulating drugs are injected directly into the tumor via endoscopic procedures. Metal-based drugs, including vanadium (V) complexes, in combination with novel delivery techniques, are promising for anti-cancer treatment. Although, the enhancement of oncolytic viruses by V compounds have shown a remarkable selectivity for cancerous tissue over normal tissue, the extensive reactivity of V complexes in biological media and associated toxicity has been regarded as the main obstacle to their translation into clinical practice. Nevertheless, the limited lifetime of typical V complexes in biological media can be turned into an advantage. Such drugs begin to kill cancer cells immediately
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