Background

Ion exchange membrane chromatography has been widely used for purification and analysis of proteins and other types of biomacromolecules. However, existing methods generally use one anion exchange membrane or one cation exchange membrane, which are difficult to achieve a high-resolution purification.

Technology Overview

To address above issue, researchers at McMaster University have developed a modulated membrane chromatography device that combines a positively charged binding membrane and a negatively charged modulating membrane, which can separate biological macromolecules with high-resolution.

Benefits

• High-resolution of separation
• Low-cost of manufacture
• Purification of hard to separate proteins such as aggregates and variants