You are viewing a preview of...

New Structural Class of Phosphononucleosides as Broad Antiviral Agents

A new structural class of phosphononucleosides with potential as broad antiviral agents against both DNA and RNA viruses

Technology Overview

Collaborative research involving University College Cork (Chemistry) and KU Leuven (Virology) has led to the design, synthesis and evaluation of a new structural class of phosphononucleosides with a novel distinctive functional feature with potential as broad antiviral agents against both DNA and RNA viruses.

The new compounds:

  • have a strong anti-viral polymerase activity
  • Have a proven new mechanism of action
  • Are drug-like
  • Have clear IP position

Further Details

  • Design and synthesis of α-carboxy nucleoside phosphonate (α-CNP) analogues and evaluation as HIV-1 reverse transcriptasetargeting agents. S. J. Keane, A. Ford, N. D. Mullins, N. M. Maguire, T. Legigan, J. Balzarini and A. R. Maguire, J. Org. Chem. 2015, 80, 2479−2493.
  • Alpha-carboxy nucleoside phosphonates as universal nucleoside

Log in or create a free account to continue reading