Background

Size exclusion chromatography (SEC) has been widely used for the analysis of biopharmaceuticals. However, limitations such as low speed, low capacity, and poor scalability of commercial SEC columns make them unsuitable for preparative purification of biopharmaceuticals.

Technology Overview

To address above issues, researchers at McMaster University have developed a scalable cuboid SEC device which has a short bed height, large cross-sectional area, and a unique flow distribution & collection system. Compared to conventional SEC columns, this novel SEC device has higher speed and productivity, lower operating pressure, higher resolution, and higher loading capacity.