Cuboid Size-Exclusion Chromatography Device
A cuboid scalable SEC device for high-resolution purification and fast separation
Background
Size exclusion chromatography (SEC) has been widely used for the analysis of biopharmaceuticals. However, limitations such as low speed, low capacity, and poor scalability of commercial SEC columns make them unsuitable for preparative purification of biopharmaceuticals.
Technology Overview
To address above issues, researchers at McMaster University have developed a scalable cuboid SEC device which has a short bed height, large cross-sectional area, and a unique flow distribution & collection system. Compared to conventional SEC columns, this novel SEC device has higher speed and productivity, lower operating pressure, higher resolution, and higher loading capacity.
Benefits
- Low operating pressure
- High loading capacity of sample
- High resolution of purification
- Fast separation
- Scalable device
Applications
- Purification of biopharmaceuticals such as antibodies, vaccines, and other life-saving therapeutics
- Purification of viruses and virus like particles (VLP)
- Purification exosomes and other vesicles
- Purification of liposomes and nanoparticles
Opportunity
McMaster University is seeking for technology licensing opportunities and research collaboration.