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Airway Organoids, Methods of Making and Uses Thereof

2D and 3D airway organoids with appreciable mucociliary differentiation and beating cilia

Background

  • Respiratory virus infections such as Influenza, are a major threat to public health worldwide.
  • The global respiratory tract infection treatment market was valued at US$ 34,276.8 Mn in 2016, and is expected to expand at a CAGR of 6.2% from 2017 to 2025.
  • The current systems for studying biology and pathology of human respiratory epithelium and infection of respiratory viruses, are human lung explant and primary human airway epithelial cell culture. However, they are neither convenient nor reproducible.
  • Human cancer cell lines have also been used to propagate viruses and to study virology. Although, they are unable to simulate human respiratory epithelia, thus inappropriate for evaluating pathophysiological attributes.
  • Therefore, a system to model human respiratory

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