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Effective mRNA Pulmonary Delivery by Dry Powder Formulation

Dry powder formulation with good aerodynamic properties for local administration of mRNA by inhalation

Background

  • Local administration of mRNA by inhalation for the treatment of lung diseases is desirable due to its non-invasive nature, increased local drug concentration and reduced systemic side effects, hence improving treatment efficacy, especially for dry powder formations
  • However, formulating mRNA into dry powder formulation is highly challenging:
    • The powder must be highly dispersible and exhibit good aerodynamic properties for effective lung deposition;
    • It is difficulty to maintain the integrity and biological activity of the mRNA during the drying process, considering that the long single stranded mRNA molecule is fragile and liable to thermal and shear stresses

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