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Natural Treatment for Ventilation-Induced Lung Injury

The use of a NRF2 inducer to reduce the lung damage caused by mechanical ventilation for patients with and without COVID-19

Background

Mechanical ventilation is used to assist patients who have difficulty breathing spontaneously in conditions such as lung trauma, chronic obstructive pulmonary disease, acute respiratory distress syndrome, apnea, severe asthma, and patients under general anesthesia. Ventilator induced lung injury may result from mechanical ventilation, which is the cyclic stretching and overdistension of the lung tissues. This causes inflammation and leads to acute lung injury. There are no effective pharmacological strategies to reduce the negative effects of mechanical ventilation.

Technology Overview

This invention is the use of an NRF2 inducer to reduce mechanical ventilator‑related lung damage by suppressing inflammatory mediators, reducing alveolar capillary leakage, and protecting against DNA oxidative damage. This can be used to treat COVID‑19 patients with ventilator-related lung

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