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A Novel Broad-spectrum Antiviral for Treating COVID-19

Peptides with potent antiviral activity against enveloped coronaviruses, influenza virus and non-enveloped rhinovirus

Background

Currently, the world is facing a pandemic situation due to coronavirus outbreak. As per WHO, the positive cases of COVID-19 across the globe rose to 416,686 with 18,589 deaths in the middle of March 2020. In addition, unavailability of a vaccine propels the COVID-19 diagnostics market growth. There is an urgent need for an effective antiviral against this virus.

Technology Overview

  • This invention is about defensin like peptides (P9 and P9R) which exhibited potent antiviral activity against enveloped coronaviruses (SARS-CoV-2, SARS-CoV and MERS-CoV), the pandemic A(H1N1) pdm09 virus, avian influenza A(H7N9) virus, and the non-enveloped rhinovirus.
  • P9R could significantly protect mice from lethal challenge by A(H1N1)pdm09 virus and showed low possibility to cause drug-resistant virus.
  • Further mechanistic studies

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