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Anti-inflammatory Biomolecule for the Suppression of LPS-induced Cytokine Storms

Natural fatty acid binding proteins suppress LPS-activated inflammatory responses mediated by TLR4, suggested to have a role in COVID-19

Background

During bacterial infections, high levels of lipopolysaccharides (LPS) in blood plasma may trigger an uncontrolled systemic inflammatory response known as sepsis. This inflammatory response to microbial endotoxins may progress to septic shock, in which the blood supply to internal organs dramatically decreases. Septic shock is a life-threatening condition that can dangerously lead to multiple organ failure and subsequent death. According to the Centers for Disease Control and Prevention, at least 1.7 million adult Americans develop sepsis each year, of which nearly 270,000 die.

Toll-like receptor 4 (TLR4) is an innate immune receptor that recognizes bacterial LPS. This transmembrane protein plays a critical role in the signaling pathways that induce cytokine storms and elicit inflammatory responses. Therefore, the scientific community

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