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Neuroimaging Biomarkers for Diagnosing Depression Subtypes and Predicting Treatment Response

Diagnostic biomarkers for depression biotypes based on whole-brain patterns of dysfunctional connectivity evaluated by fMRI

Background

  • Depression is a heterogeneous syndrome that encompasses varied, co-occurring clinical symptoms and divergent responses to treatment
  • However, the relationship between dysfunction and abnormal connectivity in the brain and clinical phenotypes is poorly understood
  • The association between clinical subtypes and their biological substrates is inconsistent and variable at the individual level, and to-date, have not proven useful for differentiating individual patients or informing treatment decisions
  • Unmet Need: Objective and clinically actionable biomarkers to diagnose subtypes of depression and guide treatment selection

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