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Neuroimaging Biomarkers for Diagnosing Depression Subtypes and Predicting Treatment Response
Diagnostic biomarkers for depression biotypes based on whole-brain patterns of dysfunctional connectivity evaluated by fMRI
- Depression is a heterogeneous syndrome that encompasses varied, co-occurring clinical symptoms and divergent responses to treatment
- However, the relationship between dysfunction and abnormal connectivity in the brain and clinical phenotypes is poorly understood
- The association between clinical subtypes and their biological substrates is inconsistent and variable at the individual level, and to-date, have not proven useful for differentiating individual patients or informing treatment decisions
- Unmet Need: Objective and clinically actionable biomarkers to diagnose subtypes of depression and guide treatment selection
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