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Natural Compounds to Regulates Winter Depression-like Behavior

New potential therapeutic targets for treating seasonal affective disorder involving NRF2

Technology Overview

To understand the underlying mechanisms of winter depression, the research group employed a chemical genomics approach using Medaka.

An in vivo broad-spectrum chemical screen identified the traditional Chinese medicine, celastrol, as rescuing winter behavior (). NRF2 is a celastrol target expressed in the habenula, known to play a critical role in the pathophysiology of depression. Although fish do not have a defined prefrontal cortex (PFC), the habenula is evolutionarily highly conserved and connects the limbic forebrain and monoaminergic system.

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