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Novel Diagnostic Assay for the Detection of SARS-CoV-2 Variant Signatures
The university's novel DTECT protocol captures SARS-CoV-2 variants from different strains with high specificity and efficiency.
Despite the implementation of government-imposed mitigation measures, nation-wide lockdowns, and world-wide travel bans, the COVID-19 pandemic has caused > 2.9million deaths. Circulating SARS-CoV-2 variants increase the risk of developing severe illness and can potentially defeat global vaccination efforts. The development and implementation of methods for rapid and reliable detection of SARS-CoV-2 variants is crucial to block their propagation.
Researchers have previously established Dinucleotide signaTurE CapTure (DTECT), a multistep approach that enables sequencing-free capture-based detection of pathogenic variants inhuman disorders or mutations introduced by modern CRISPR-based genome editing technologies. The university’s novel DTECT protocol captures SARS-CoV-2 variants from different strains with high specificity and efficiency. The rapid method will facilitate its implementation into standard RTPCR platforms for the
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