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Colorimetric Aptasensor for the Rapid Diagnosis of SARS-CoV-2 (Covid-19)

A cost-effective, rapid colorimetric aptasensor binding to SARS-CoV-2 RBD with significantly high affinities for the diagnosis of Covid-19

Background

The outbreak of Covid-19, which is caused by the novel corona virus SARS-CoV-2, is now a global pandemic. Development of rapid and portable tests at a point of sampling/testing would be an invaluable weapon all over the world to curb the spread of the virus. The receptor-binding domain (RBD) of SARS-CoV-2 spike glycoprotein is responsible for the binding specificity of the virus to host cells, making the RBD a key target for diagnosis, treatment, and vaccine development. Although the SARS-CoV S and SARS-CoV-2 S proteins share some structural homology and use the same host receptor, the monoclonal antibodies generated against SARS-CoV RBD do not bind to SARS-CoV-2 RBD, which makes their use in diagnosis of the latter impossible. This

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