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Small Molecule Anti-Cancer Therapeutic with Potential for Reduced Toxicity

Compound targeting the inhibition of nuclear transport protein Karyopherin beta (β) 1 (Kpnβ1)

Background

Central to the wellbeing of any living organism is the nucleus of the cell. It stores and organises genetic information and protects this information from other cellular components. The nucleus also communicates with the rest of the cell, exchanges proteins and RNA, and facilitates several important processes.

The nuclear pore complex (NPC) is a large protein complex that is responsible for the exchange of components between the nucleus and cytoplasm. It is also essential for blocking materials not meant to cross into the nucleus.

Karyopherin β1 (Kpnβ1), also known as Importin β, is a major nuclear import receptor that transports proteins containing a nuclear localisation signal (NLS) through the nuclear pore complex (NPC) into the nucleus. Not

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