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Novel Phage Surface for Bidirectional Stem Cell Differentiation

Unique NiM structure allows for quick differentiation of hiPSC-derived NPCs into both neurons and astrocytes in the absence of any inducer

Background

Therapeutic development aimed at neurodegenerative diseases (NDD) such as Parkinson’s disease and Alzheimer’s disease focus on probing the structure, function, and interactions of neurons and astrocytes. Traditional neural regenerative studies utilize rat cells for generating a neuron-astrocyte coculture. There are very limited nanomaterials with which to achieve the neuron-astrocyte coculture model from a human cell source. There is a pressing need to simultaneously generate (and regenerate) compatible human neurons and astrocytes in a coculture model for increasing the reliability of NDD treatment strategies.

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