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Modified ACE2 (mACE2) - A High-Affinity Binder for SARS-CoV-2

Applications in the detection of SARS-CoV-2 viral particles, including potential application in a point-of-care diagnostic assay

Technology Overview

SARS-CoV-2 gains access to the host cell through the interaction of the coronavirus spike (S) protein with the human angiotensin-converting enzyme 2 (ACE2). Using computational protein engineering methods, researchers have redesigned natural ACE2 to develop a catalytically dead and stable protein, modified ACE2 (mACE2), with high binding affinity and specificity to the S protein. mACE2, which was recombinantly produced in high yields in an E. coli expression system, shows very high thermal stability and interacts with the receptor binding domain (RBD) of the S protein with nanomolar affinity.

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