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Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments

A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites

Background

Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier design generally follows a “trial and error” approach using a limited number nanoparticle types to fit a variety of drug molecules that exhibit substantial chemical variation. This approach results in suboptimal nano-formulations with compromised efficiency for in vivo drug delivery and decreased probability of successful clinical translation. In contrast, the suite of innovations described herein offer a customized nanocarrier platform with the capability of structure-based design and systematic optimization to bridge the gap for nanomedicine in clinical translation.

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