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Complement Protein with Anti-inflammatory Activity

Novel mechanism for the development of new therapeutic concepts for the treatment of autoimmune diseases, transplantation, or allergy.


The human complement system is, as part of the innate immune system, responsible for the defence against invading pathogens. Complement activation is tightly regulated, leading to the generation of a series of complement split products (such as C4d) from inactive precursor molecules that ultimately lead to the destruction of invading pathogens and their clearance from the body.

Split product C4d itself has been an orphan ligand with no known attributed function per se. However, in some studies it was associated with the autoimmune syndrome systemic lupus erythematosus, and presence of C4d in renal allografts is an established marker of antibody-mediated graft rejection.

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